Epothilone

• Anti-cancer drug. Same binding site as [[Paclitaxel

  taxol]]

• Macrolide natural product
• Thiazol

[! tip]- Heterocyclic nomenclature Remember common five member ring nomenclature:

• completely unsaturated: pyrrol, furan, imidazol, oxazol, thiophene, thiazol
• partially saturated: pyrroline, oxazolin, thiazolin
• completely saturated: pyrrolidine, oxazolidine, thiazolidine

Nicolau synthesis

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Biosynthesis