Alkylating nitrogen mustards
Name | Structure |
---|---|
Chloambucil | ![]() |
Cyclophosphamide | ![]() |
Ifosfamide | ![]() |
Questions
- Compare alkylating ability of mustine shown below to the more recently developed nitrogen mustards from the table above.
- Suggest a method to prepare HN3 shown below.
- Use resonance to rationalize which position of guanine would be preferentially alkylated by these agents.
- Would you expect nitrogen mustards to cross link bases from the same DNA strand or from different strands? How does this compare to the action of cis-platin?