Cyclin-dependent kinases

  • division of cells is highly regulated
  • cyclins and cyclin dependent kinases control cell division
  • [[cell cycle]]
  • cyclins are kept low through protein degradation (ubiquitine-proteasome system)
  • when needed, cyclin binds CDK, kinase phosphorylates itself and starts phosphorylating other proteins
  • PDB101
    • PDB 1fin ; cyclin bound to CDK
    • PDB 1qmz cyclin+CDK+peptide target
    • PDB 1bi7 CDK+INK proteins (if DNA is damaged and needs to be repaired prior to DNA replication in S phase)
    • PDB 1jsu CDK + Kip protein that prevents ATP from binding


  1. What are some small molecule CDK6 inhibitors?