Cyclin-dependent kinases
- division of cells is highly regulated
- cyclins and cyclin dependent kinases control cell division
- [[cell cycle]]
- cyclins are kept low through protein degradation (ubiquitine-proteasome system)
- when needed, cyclin binds CDK, kinase phosphorylates itself and starts phosphorylating other proteins
- PDB101
- PDB 1fin ; cyclin bound to CDK
- PDB 1qmz cyclin+CDK+peptide target
- PDB 1bi7 CDK+INK proteins (if DNA is damaged and needs to be repaired prior to DNA replication in S phase)
- PDB 1jsu CDK + Kip protein that prevents ATP from binding
Questions
- What are some small molecule CDK6 inhibitors?