Cyclin-dependent kinases

division of cells is highly regulated
cyclins and cyclin dependent kinases control cell division
[[cell cycle]]
cyclins are kept low through protein degradation (ubiquitine-proteasome system)
when needed, cyclin binds CDK, kinase phosphorylates itself and starts phosphorylating other proteins
PDB101
- PDB 1fin ; cyclin bound to CDK
- PDB 1qmz cyclin+CDK+peptide target
- PDB 1bi7 CDK+INK proteins (if DNA is damaged and needs to be repaired prior to DNA replication in S phase)
- PDB 1jsu CDK + Kip protein that prevents ATP from binding