Mutations at the drug binding sites
- Choose a cancer drug whose protein target is known.
- Find a crystal structure of the drug binding to its protein target and open the structure in PyMOL.
- Inspect the binding site and select the residues near the drug binding site.
- Search the literature for common mutations in the target protein that cause resistance to the cancer drug.
- Map these amino acids to the protein.
- Repeat for another cancer drug.