Metabolism and cancer
The link between metabolism and cancer is, perhaps unsuprisingly, very strong.
Tasks:
- Explain the “Warburg effect”
- Discuss the meaning of the term oncometabolite.
- How does the most famous oncometabolite, 2-hydroxyglutarate, exert its activity? Discuss the chemistry.
- From the list of these additional oncometabolites (glucose, fumarate, succinate, sarcosine, glutamine, asparagine, choline, and lactate) select one and describe its action.
- Explain the the relationship between the reactive oxygen species (ROS) and cancer.
- Explain the NRF-Keap pathway.