Alkylating agents

Alkylating agents are drugs that yield an unstable alkyl group, R-CH2+, reacting with nucleophilic centers on proteins and nucleic acids. They can inhibit DNA replication and transcription.

Toxicity: Dose-limiting toxicity: myelosuppression (neutropenia nadir: 6 to 10 days with recovery in 14 to 21 days). Mucositis, nausea and vomiting, neurotoxicity, alopecia. Long-term toxicities: pulmonary fibrosis, infertility, secondary malignancies.

See nitrogen mustards

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