MDCM790

Material

  1. Introduction
    1. What is cancer?
    2. Hallmarks of cancer
    3. Cancer-driving mutations
    4. Oncogenes
    5. Chemotherapy principles
  2. Interfering with the DNA
    1. DNA damage
    2. Topoisomerase inhibition
  3. Interfering with the cytoskeleton
    1. Microtubules
    2. Tubulin-binding drugs
  4. Transcription factors
    1. Myc
    2. p53
    3. Anti-hormone therapy
  5. Signaling
    1. Anti-growth factor
    2. Ras signaling
    3. Anti-metabolites
  6. Interfering with epigenetics
  7. Immunotherapy
    1. Engineered immune cells
    2. Antibodies
    3. Cyclin-dependent kinases
  8. Target degradation
  9. Data portals for cancer research

Research projects

  1. Mutations at the drug binding sites
  2. Metabolism and cancer
  3. Small molecules that cleave DNA
  4. Histone “code”
  5. Discovering cancer dependencies from data